[CAS NO. 625110-37-4] TS-021 free base
PRODUCTS SPECIFICATIONS [625110-37-4]
DESCRIPTION [625110-37-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 243.28 |
| Molecular Formula | C11H18FN3O2 |
| SMILES | N#C[C@H]1N(C(CNC(C)(C)CO)=O)C[C@@H](F)C1 |
Summary
DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) , a highly specific serine protease , with an IC 50 of 4.6 nM.
In Vivo
DPP-IV-IN-1 (0.1 and 0.3 mg/kg, p.o.) reduces the increase in plasma glucose beginning 30 min after glucose loading, and significantly suppresses hyperglycemia at the dose of 0.3 mg/kg in a rat model of obesity and impaired glucose tolerance. The effect is based on its inhibitory effect on plasma DPP-IV activity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 513.81 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.1105 mL | 20.5525 mL | 41.1049 mL |
| 5 mM | 0.8221 mL | 4.1105 mL | 8.2210 mL |
| 10 mM | 0.4110 mL | 2.0552 mL | 4.1105 mL |