[CAS NO. 632-85-9] Wogonin

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PRODUCTS SPECIFICATIONS [632-85-9]

Catalog

HY-N0400

Brand

MCE

CAS

632-85-9

DESCRIPTION [632-85-9]

Overview

MDL	MFCD00017736
Molecular Weight	284.26
Molecular Formula	C16H12O5
SMILES	O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13

For research use only. We do not sell to patients.

9 Publications Citing Use of MCE

Summary

Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt , and exhibits anti-inflammatory and anti-tumor effects.

IC50 & Target

CDK8

In Vitro

Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8 ^[1] . Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 µM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells ^[2] . Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model ^[1] . Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 219.87 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5179 mL	17.5895 mL	35.1791 mL
5 mM	0.7036 mL	3.5179 mL	7.0358 mL
10 mM	0.3518 mL	1.7590 mL	3.5179 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 0.5% CMC-Na /saline water

Solubility: 24 mg/mL (84.43 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.08 mg/mL (7.32 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

Synonyms

4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-

Flavone, 5,7-dihydroxy-8-methoxy-

Wogonin

5,7-Dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one

5,7-Dihydroxy-8-methoxyflavone