[CAS NO. 63335-24-0] Malabaricone B
PRODUCTS SPECIFICATIONS [63335-24-0]
DESCRIPTION [63335-24-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 342.43 |
| Molecular Formula | C21H26O4 |
| SMILES | O=C(C1=C(O)C=CC=C1O)CCCCCCCCC2=CC=C(O)C=C2 |
Summary
In Vitro
Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC
50
= 8.1 μM), which is significantly better than that of curcumin (IC
50
= 26.7 μM)
[1]
.
The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 µM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3
[1]
.
Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including
Staphylococcus aureus
and
Candida albicans
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 292.03 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9203 mL | 14.6015 mL | 29.2030 mL |
| 5 mM | 0.5841 mL | 2.9203 mL | 5.8406 mL |
| 10 mM | 0.2920 mL | 1.4602 mL | 2.9203 mL |
References
- [1] Mrityunjay Tyagi, et al. Spice-derived phenolic, malabaricone B induces mitochondrial damage in lung cancer cells via a p53-independent pathway. Food Funct. 2018 Nov 14;9(11):5715-5727.
- [2] K Y Orabi, et al. Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans). J Nat Prod. May-Jun 1991;54(3):856-9.
- [3] B Prabha, et al. Antidiabetic potential of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.) Sinclair. Bioorg Med Chem. 2018 Jul 23;26(12):3461-3467.