[CAS NO. 63388-44-3] SJB2-043
PRODUCTS SPECIFICATIONS [63388-44-3]
DESCRIPTION [63388-44-3]
Overview
| MDL | MFCD26960957 |
|---|---|
| Molecular Weight | 275.26 |
| Molecular Formula | C17H9NO3 |
| SMILES | O=C1C2=C(N=C(C3=CC=CC=C3)O2)C(C4=CC=CC=C41)=O |
3 Publications Citing Use of MCE
Summary
SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC 50 of 544 nM.
IC50 & Target
IC50: 544 nM (USP1/UAF1) [1]
In Vitro
SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC 50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 3.33 mg/mL ( 12.10 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6329 mL | 18.1646 mL | 36.3293 mL |
| 5 mM | 0.7266 mL | 3.6329 mL | 7.2659 mL |
| 10 mM | 0.3633 mL | 1.8165 mL | 3.6329 mL |