[CAS NO. 635324-72-0] B7/CD28 interaction inhibitor 1
PRODUCTS SPECIFICATIONS [635324-72-0]
DESCRIPTION [635324-72-0]
Overview
| MDL | MFCD28127008 |
|---|---|
| Molecular Weight | 427.35 |
| Molecular Formula | C21H13F4N5O |
| SMILES | O=C1N(C2=CC=C(F)C=C2)NC3=C4C(N(C)N=C4)=NC(C5=CC=CC(C(F)(F)F)=C5)=C31 |
Summary
B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC 50 of 50 nM [1] .
IC50 & Target
IC50: 50 nM (B7.1-CD28 interaction) [1]
In Vitro
Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 146.25 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3400 mL | 11.7000 mL | 23.4000 mL |
| 5 mM | 0.4680 mL | 2.3400 mL | 4.6800 mL |
| 10 mM | 0.2340 mL | 1.1700 mL | 2.3400 mL |
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