[CAS NO. 638156-11-3] CID2011756
PRODUCTS SPECIFICATIONS [638156-11-3]
DESCRIPTION [638156-11-3]
Overview
| MDL | MFCD04094273 |
|---|---|
| Molecular Weight | 396.87 |
| Molecular Formula | C22H21ClN2O3 |
| SMILES | O=C(C1=CC=C(C2=CC=CC(Cl)=C2)O1)NC3=CC=C(CN4CCOCC4)C=C3 |
Summary
IC50 & Target
IC50: 3.2 µM (PKD1), 0.6 µM (Cellular PKD2), 0.7 µM (Cellular PKD3) [1]
In Vitro
CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC 50 of 3.2 µM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser 916 in LNCaP cancer cells with an EC 50 of 10±0.7 µM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC 50 s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 20 mg/mL ( 50.39 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5197 mL | 12.5986 mL | 25.1972 mL |
| 5 mM | 0.5039 mL | 2.5197 mL | 5.0394 mL |
| 10 mM | 0.2520 mL | 1.2599 mL | 2.5197 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2 mg/mL (5.04 mM); Clear solution