[CAS NO. 6385-02-0] Meclofenamic acid sodium

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PRODUCTS SPECIFICATIONS [6385-02-0]

Catalog

HY-B1320

Brand

MCE

CAS

6385-02-0

DESCRIPTION [6385-02-0]

Overview

MDL	MFCD00077376
Molecular Weight	318.13
Molecular Formula	C14H10Cl2NNaO2
SMILES	O=C(O[Na])C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

Meclofenamic acid (Meclofenamate) sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor ^[1] ^[2] ^[3] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02930005	The University of Texas Health Science Center, Houston	Psychotic Disorders\|Schizophrenia\|Schizoaffective Disorder\|Bipolar Disorder	August 7, 2015	Phase 2
NCT02429570	Memorial Sloan Kettering Cancer Center	Recurrent Brain Metastases\|Progressive Brain Metastases	April 22, 2015	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 392.92 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1434 mL	15.7168 mL	31.4337 mL
5 mM	0.6287 mL	3.1434 mL	6.2867 mL
10 mM	0.3143 mL	1.5717 mL	3.1434 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1)

Anthranilic acid, N-(2,6-dichloro-m-tolyl)-, monosodium salt

Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, monosodium salt

Sodium meclophenamate

Sodium meclofenamate

Sodium N-(2,6-dichloro-m-tolyl)anthranilate

N-(2,6-Dichloro-m-tolyl)anthranilic acid sodium salt

Meclomen

CI 583

Meclofenamate sodium

Meclofenamic acid sodium salt