[CAS NO. 639052-78-1] LH846
PRODUCTS SPECIFICATIONS [639052-78-1]
DESCRIPTION [639052-78-1]
Overview
| MDL | MFCD03786038 |
|---|---|
| Molecular Weight | 316.81 |
| Molecular Formula | C16H13ClN2OS |
| SMILES | O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3 |
1 Publications Citing Use of MCE
Summary
LH846 is a selective inhibitor of CKIδ , with an IC 50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC 50 s of 2.5 μM and 1.3 μM, respectively.
IC50 & Target
|
CKIδ 290 nM (IC 50 ) |
CKIα 2.5 μM (IC 50 ) |
In Vitro
LH846 is a potent inhibitor of CKIδ, with an IC 50 of 290 nM, less potently inhibits CKIα and CKIε, with IC 50 s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 45 mg/mL ( 142.04 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1565 mL | 15.7823 mL | 31.5647 mL |
| 5 mM | 0.6313 mL | 3.1565 mL | 6.3129 mL |
| 10 mM | 0.3156 mL | 1.5782 mL | 3.1565 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.89 mM); Clear solution