[CAS NO. 64302-87-0] R162
PRODUCTS SPECIFICATIONS [64302-87-0]
DESCRIPTION [64302-87-0]
Overview
| MDL | MFCD00666806 |
|---|---|
| Molecular Weight | 264.28 |
| Molecular Formula | C17H12O3 |
| SMILES | O=C1C2=C(C=CC=C2)C(C3=CC=C(CC=C)C(O)=C13)=O |
5 Publications Citing Use of MCE
Summary
R162 is a potent inhibitor of glutamate dehydrogenase 1 ( GDH1 / GLUD1 ), with anti-cancer properties.
In Vitro
Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMF : 6.25 mg/mL ( 23.65 mM ; ultrasonic and warming and heat to 60°C)
DMSO : 5.2 mg/mL ( 19.68 mM ; Need ultrasonic)
Ethanol : 2 mg/mL ( 7.57 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (ultrasonic) (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7839 mL | 18.9193 mL | 37.8387 mL |
| 5 mM | 0.7568 mL | 3.7839 mL | 7.5677 mL |
| 10 mM | 0.3784 mL | 1.8919 mL | 3.7839 mL |