[CAS NO. 6601-66-7] 6-Demethoxytangeretin
PRODUCTS SPECIFICATIONS [6601-66-7]
DESCRIPTION [6601-66-7]
Overview
| MDL | MFCD03427696 |
|---|---|
| Molecular Weight | 342.34 |
| Molecular Formula | C19H18O6 |
| SMILES | O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=CC(OC)=C13 |
Summary
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata . 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase ( ALK ) and mitogen-activated protein kinase ( MAPK ) pathways [1] . 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 12.5 mg/mL ( 36.51 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9211 mL | 14.6054 mL | 29.2107 mL |
| 5 mM | 0.5842 mL | 2.9211 mL | 5.8421 mL |
| 10 mM | 0.2921 mL | 1.4605 mL | 2.9211 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1.25 mg/mL (3.65 mM); Clear solution
References
- [1] Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5.
- [2] Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.
Synonyms