[CAS NO. 66056-22-2] Angeloylgomisin H

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PRODUCTS SPECIFICATIONS [66056-22-2]

Catalog

HY-N2209

Brand

MCE

CAS

66056-22-2

DESCRIPTION [66056-22-2]

Overview

MDL	-
Molecular Weight	500.58
Molecular Formula	C28H36O8
SMILES	O=C(/C(C)=C\C)OC(C(OC)=C(OC)C=C1CC(C)C(C)(O)C2)=C1C3=C2C=C(OC)C(OC)=C3OC

For research use only. We do not sell to patients.

Summary

Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora , has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ ^[1] .

IC50 & Target

PPAR-γ

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 499.42 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9977 mL	9.9884 mL	19.9768 mL
5 mM	0.3995 mL	1.9977 mL	3.9954 mL
10 mM	0.1998 mL	0.9988 mL	1.9977 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Chen S, et al. Pharmacokinetic and bioavailability study of angeloylgomisin H in rat plasma by UPLC-MS/MS. Int J Clin Exp Med. 2015 Oct 15;8(10):17968-76.

Synonyms

2-Butenoic acid, 2-methyl-, (6S,7S,12aR)-5,6,7,8-tetrahydro-7-hydroxy-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-1-yl ester, (2Z)-

2-Butenoic acid, 2-methyl-, 5,6,7,8-tetrahydro-7-hydroxy-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-1-yl ester, stereoisomer

Dibenzo[a,c]cyclooctene, 2-butenoic acid deriv.

Angeloylgomisin H

(+)-Angeloylgomisin H