[CAS NO. 662164-09-2] D3-βArr

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PRODUCTS SPECIFICATIONS [662164-09-2]

Catalog

HY-124867

Brand

MCE

CAS

662164-09-2

DESCRIPTION [662164-09-2]

Overview

MDL	MFCD04077665
Molecular Weight	333.43
Molecular Formula	C20H23N5
SMILES	CC(NC1=C2C=CC=CC2=NC(N3CCNCC3)=N1)C4=CC=CC=C4

For research use only. We do not sell to patients.

Summary

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) , which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro ^[1] .

IC50 & Target

Thyrotropin receptor (TSHR) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL ( 374.89 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9991 mL	14.9957 mL	29.9913 mL
5 mM	0.5998 mL	2.9991 mL	5.9983 mL
10 mM	0.2999 mL	1.4996 mL	2.9991 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.