[CAS NO. 672-87-7] Metyrosine

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PRODUCTS SPECIFICATIONS [672-87-7]

Catalog

HY-W015007

Brand

MCE

CAS

672-87-7

DESCRIPTION [672-87-7]

Overview

MDL	MFCD00064201
Molecular Weight	195.22
Molecular Formula	C10H13NO3
SMILES	C[C@](C(O)=O)(N)CC1=CC=C(O)C=C1

For research use only. We do not sell to patients.

Summary

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity ^[1] . Metyrosine is a very effective agent for blood pressure control ^[2] .

In Vitro

Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation ^[1] .
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male albino Wistar rats (carrageenan-induced rat paw edema) ^[2]
Dosage:	50, 100 or 200 mg/kg
Administration:	I.p.
Result:	Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01127503	Bausch Health Americas, Inc.	Velo-cardio-facial Syndrome\|Psychosis	June 2010	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H ₂ O : 5 mg/mL ( 25.61 mM ; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1224 mL	25.6121 mL	51.2243 mL
5 mM	1.0245 mL	5.1224 mL	10.2449 mL
10 mM	0.5122 mL	2.5612 mL	5.1224 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

L-Tyrosine, α-methyl-

Tyrosine, α-methyl-, L-

α-Methyl-L-tyrosine

L-α-Methyltyrosine

L-α-Methyl-p-tyrosine

Metyrosine

(S)-α-Methyltyrosine

L(-)-Metyrosine

Metirosine

Demser

L-Metyrosine

MK 781

L-α-MT

(S)-2-(4-Hydroxybenzyl)-2-aminopropanoic acid

(2S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid