[CAS NO. 672926-33-9] Kif15-IN-2

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PRODUCTS SPECIFICATIONS [672926-33-9]

Catalog

HY-15949

Brand

MCE

CAS

672926-33-9

DESCRIPTION [672926-33-9]

Overview

MDL	-
Molecular Weight	440.48
Molecular Formula	C20H20N6O4S
SMILES	O=C(C1=CC=CC=C1N2)N([C@@H](C(C)C)C(NC3=NC(C)=C(C4=NN=C(C)O4)S3)=O)C2=O

For research use only. We do not sell to patients.

Summary

Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15 , and is used for the research of cellular proliferative diseases.

IC50 & Target

KIF15

In Vitro

Kif15-IN-2 (Compound 14) is an inhibitor of the mitotic kinesin Hs Kif15, with the potential activities against cellular proliferative diseases such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL ( 45.41 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2703 mL	11.3513 mL	22.7025 mL
5 mM	0.4541 mL	2.2703 mL	4.5405 mL
10 mM	0.2270 mL	1.1351 mL	2.2703 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2 mg/mL (4.54 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2 mg/mL (4.54 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Quinazolinedione derivatives useful for treating cellular proliferative disorders and disorders associated with Kif15 kinesin activity are described. US 20040053948 A1.

Synonyms

3(2H)-Quinazolineacetamide, 1,4-dihydro-α-(1-methylethyl)-N-[4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)-2-thiazolyl]-2,4-dioxo-, (αS)-

(αS)-1,4-Dihydro-α-(1-methylethyl)-N-[4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)-2-thiazolyl]-2,4-dioxo-3(2H)-quinazolineacetamide

(2S)-2-(2,4-Dioxo-1H-quinazolin-3-yl)-3-methyl-N-[4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)-1,3-thiazol-2-yl]butanamide