[CAS NO. 67483-13-0] DIDS sodium salt
PRODUCTS SPECIFICATIONS [67483-13-0]
DESCRIPTION [67483-13-0]
Overview
| MDL | MFCD00009638 |
|---|---|
| Molecular Weight | 498.48 |
| Molecular Formula | C16H8N2Na2O6S4 |
| SMILES | O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(N=C=S)C=C2S(=O)(O[Na])=O)(O[Na])=O |
7 Publications Citing Use of MCE
Summary
DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor.
In Vitro
Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL ( 250.76 mM ; ultrasonic and warming and heat to 60°C)
H 2 O : 33.33 mg/mL ( 66.86 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0061 mL | 10.0305 mL | 20.0610 mL |
| 5 mM | 0.4012 mL | 2.0061 mL | 4.0122 mL |
| 10 mM | 0.2006 mL | 1.0030 mL | 2.0061 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (4.17 mM); Clear solution
References
- [1] Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810.
- [2] Chen H, et al. Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19(12):1712-26.