[CAS NO. 67884-30-4] Gigantol isomer-1
PRODUCTS SPECIFICATIONS [67884-30-4]
DESCRIPTION [67884-30-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 274.31 |
| Molecular Formula | C16H18O4 |
| SMILES | COC1=CC(O)=CC(CCC2=CC(O)=C(OC)C=C2)=C1 |
1 Publications Citing Use of MCE
Summary
Gigantol is a bibenzyl compound derived from Dendrobium nobile . Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.
IC50 & Target
Wnt [1]
In Vitro
Gigantol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduces the level of phosphorylated LRP6 [1] . Gigantol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol at concentrations of 1, 40 and 150 µM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC 50 value is 9.30 µM [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
LDD and gigantol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 364.55 mM )
Ethanol : 50 mg/mL ( 182.28 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6455 mL | 18.2276 mL | 36.4551 mL |
| 5 mM | 0.7291 mL | 3.6455 mL | 7.2910 mL |
| 10 mM | 0.3646 mL | 1.8228 mL | 3.6455 mL |
References
- [1] Yu S, et al. Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complement Altern Med. 2018 Feb 14;18(1):59.
- [2] Chen H, et al. Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway. Oncol Rep. 2017 Feb;37(2):865-870.
- [3] Déciga-Campos M, et al. Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa. J Ethnopharmacol. 2007 Nov 1;114(2):161-8.
Synonyms