[CAS NO. 68-96-2]  17α-Hydroxyprogesterone

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PRODUCTS SPECIFICATIONS [68-96-2]

Catalog
HY-B0891
Brand
MCE
CAS
68-96-2

DESCRIPTION [68-96-2]

Overview

MDL-
Molecular Weight330.46
Molecular FormulaC21H30O3
SMILESCC([C@@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE


Summary

17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.


IC50 & Target

Human Endogenous Metabolite


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT03433040 University of South Florida|Washington University School of Medicine
Premature Birth|Absorption; Chemicals
August 23, 2017 Phase 3
NCT01050647 Stanford University
Pregnancy Complications
February 2010 Phase 1|Phase 2
NCT04807543 Ain Shams University
Preterm Premature Rupture of Membrane
January 10, 2018 Phase 2

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 151.30 mM ; Need ultrasonic)

H 2 O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0261 mL 15.1304 mL 30.2609 mL
5 mM 0.6052 mL 3.0261 mL 6.0522 mL
10 mM 0.3026 mL 1.5130 mL 3.0261 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.57 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.57 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

Pregn-4-ene-3,20-dione, 17-hydroxy-
17-Hydroxypregn-4-ene-3,20-dione
17-Hydroxyprogesterone
Prodox
17α-Hydroxypregn-4-ene-3,20-dione
Hydroxyprogesterone
Δ4-Pregnen-17α-ol-3,20-dione
Gestageno Gador
Prodix
Pregn-4-en-17α-ol-3,20-dione
17α-Hydroxyprogesterone
U 3096
Gestageno
NSC 15468
17α-Hydroxylutin
17α-Hydroxy-P4
4-Pregnene-17α-ol-3,20-dione