[CAS NO. 681136-29-8] JNJ-1661010
PRODUCTS SPECIFICATIONS [681136-29-8]
DESCRIPTION [681136-29-8]
Overview
| MDL | MFCD00209157 |
|---|---|
| Molecular Weight | 365.45 |
| Molecular Formula | C19H19N5OS |
| SMILES | O=C(NC1=CC=CC=C1)N(CC2)CCN2C3=NC(C4=CC=CC=C4)=NS3 |
Summary
IC50 & Target
IC50: 34 nM (rat FAAH) and 33 nM (human FAAH) [1]
In Vivo
JNJ-1661010 (Takeda-25; i.p.; 50 mg/kg) diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model
[2]
.
JNJ-1661010 (i.p.; 10 mg/kg) has a T
1/2
of 35 mins, a CL of 0.032 mL/min/kg, and a C
max
of 1.58 μM for rats
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 273.64 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7364 mL | 13.6818 mL | 27.3635 mL |
| 5 mM | 0.5473 mL | 2.7364 mL | 5.4727 mL |
| 10 mM | 0.2736 mL | 1.3682 mL | 2.7364 mL |
References
- [1] Keith JM, et al. Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43.
- [2] Karbarz MJ, et al. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylicacid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg. 2009 Jan;108(1):316-29.