[CAS NO. 681159-27-3] CBR-5884

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PRODUCTS SPECIFICATIONS [681159-27-3]

Catalog

HY-100012

Brand

MCE

CAS

681159-27-3

DESCRIPTION [681159-27-3]

Overview

MDL	MFCD04451442
Molecular Weight	336.39
Molecular Formula	C14H12N2O4S2
SMILES	O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC

For research use only. We do not sell to patients.

13 Publications Citing Use of MCE

Summary

CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC ₅₀ of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis ^[1] .

IC50 & Target

PHGDH, serine synthesis ^[1]

In Vitro

CBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay ^[1]

Cell Line:	Breast and melanoma cell lines
Concentration:	15 or 30 μM
Incubation Time:	3-5 days
Result:	Inhibited the proliferation of melanoma and breast cancer lines.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 148.64 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9727 mL	14.8637 mL	29.7274 mL
5 mM	0.5945 mL	2.9727 mL	5.9455 mL
10 mM	0.2973 mL	1.4864 mL	2.9727 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.18 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Proc Natl Acad Sci U S A, 2016 Feb 16, 113(7):1778-83.