[CAS NO. 6833-84-7] Nonactin
PRODUCTS SPECIFICATIONS [6833-84-7]
DESCRIPTION [6833-84-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 736.93 |
| Molecular Formula | C40H64O12 |
| SMILES | O=C(O[C@H](C)C[C@@]1([H])CC[C@@](O1)([H])[C@H](C)C(O[C@@H](C)C[C@]2([H])CC[C@](O2)([H])[C@@H](C)C(O[C@H](C)C[C@@]3([H])CC[C@@](O3)([H])[C@@H]4C)=O)=O)[C@H](C)[C@@](O5)([H])CC[C@@]5([H])C[C@H](C)OC4=O |
Summary
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus . Nonactin acts as an ionophore for monovalent cations, including K + , and NH 4 + [1] . Nonactin is able to uncouple the oxidative phosphorylation ( OXPHOS ) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin [2] . Nonactin inhibits the surface expression of endogenous HSP60 [3] .
Appearance
Solid
Source
Streptomyces griseus ETH A7796
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMF : 50 mg/mL ( 67.85 mM ; ultrasonic and warming and heat to 60°C)
DMSO : 6.67 mg/mL ( 9.05 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3570 mL | 6.7849 mL | 13.5698 mL |
| 5 mM | 0.2714 mL | 1.3570 mL | 2.7140 mL |
| 10 mM | 0.1357 mL | 0.6785 mL | 1.3570 mL |
References
- [1] Martínez-Haya B, et al. On the ionophoric selectivity of nonactin and related macrotetrolide derivatives. Phys Chem Chem Phys. 2017 Jan 4;19(2):1288-1297.
- [2] Shikata Y, et al. Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci. 2017 Apr;108(4):772-784.
- [3] Barazi HO, et al. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002 Mar 1;62(5):1541-8.
Synonyms