[CAS NO. 68902-57-8] Metioprim
PRODUCTS SPECIFICATIONS [68902-57-8]
DESCRIPTION [68902-57-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 306.38 |
| Molecular Formula | C14H18N4O2S |
| SMILES | NC1=NC(N)=C(CC2=CC(OC)=C(C(OC)=C2)SC)C=N1 |
Summary
Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR) . Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli . and various mycobacteria [1] [2] .
In Vitro
Metioprim inhibits some anaerobic bacteria species with an average MIC value of 3.2 μg/mL
[1]
.
Metioprim (0-1.0 μM; 0-8 h) suppresses bacterial growth kinetics, and inhibits
E. coli
with an MIC value of 0.7 μg/mL
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Metioprim (5 mg/kg or 10 mg/kg; i.v.; single dose) has a shorter elimination half-life in goat than in pig (23 min vs 169 min), and its main metabolites are methionine sulfoxide and methoxysulfonic acid
[3]
.
Pharmacokinetic Analysis
[1]
| Animal | Route | Dose (mg/kg) | C 0 (μg/mL) | A (μg/mL) | α (1/min) | t 1/2α (min) | B (μg/mL) | β (1/min) | t 1/2β (min) | V C (1/kg) | V p (1/kg) | V d,ss (1/kg) | Cl β (mL/min/kg) |
| Pigs | i.v. | 5 | 3.6 | 2.1 | 0.032 | 25 | 1.5 | 0.00415 | 169 | 1.45 | 0.74 | 2.19 | 10.0 |
| Goats | i.v. | 10 | 12.2 | 6.4 | 0.220 | 4 | 5.6 | 0.03138 | 23 | 0.85 | 0.44 | 1.28 | 49 |
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Wüst J, et al. Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria. Antimicrob Agents Chemother. 1983 Mar;23(3):490-2.
- [2] Seydel JK, et al. Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). Chemotherapy. 1983;29(4):249-61.
- [3] Nielsen P, et al. Pharmacokinetics and metabolism of metioprim in pigs and goats. Pharmacol Toxicol. 1987 Nov;61(5):330-4.