[CAS NO. 69-57-8] Penicillin G sodium salt

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PRODUCTS SPECIFICATIONS [69-57-8]

Catalog

HY-B1463

Brand

MCE

CAS

69-57-8

DESCRIPTION [69-57-8]

Overview

MDL	MFCD00069666
Molecular Weight	356.37
Molecular Formula	C16H17N2NaO4S
SMILES	O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O[Na]

For research use only. We do not sell to patients.

7 Publications Citing Use of MCE

Summary

Penicillin G sodium salt is a typical β-lactam antibiotic .

IC50 & Target

β-lactam

In Vitro

The Ultraviolet-visible (UV-Vis) absorption spectrum of the Penicillin G sodium salt-TEM-1 system is markedly different to that of Penicillin G sodium salt and TEM-1 β-lactamase, indicating the formation of new complexes between Penicillin G sodium salt and TEM-1 β-lactamase. The UV-Vis absorption of TEM-1 β-lactamase increases and a slight red-shift occurs as the concentration of Penicillin G sodium salt increasing, indicating that the interaction between Penicillin G sodium salt and TEM-1 β-lactamase results in subtle conformational changes of TEM-1 β-lactamase ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the logistic regression model, the probability of a positive swab in the control group is 1.6 times higher than that in the pigs treated with Penicillin G sodium salt (P<0.05). In the control group, the risk of a swab having 10 to 99 colonies per plate, compare to having zero per plate, is 2.3 times greater than that in the pigs treated with Penicillin G sodium salt (P=0.022) ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05211024	Children´s Hospital Medical Center, Cincinnati\|Uganda Heart Institute, Kampala, Uganda\|Murdoch Children´s Research Institute, Melbourne Australia	Rheumatic Heart Disease	January 28, 2022
NCT03660488	University of California, Los Angeles\|AIDS Healthcare Foundation	Syphilis\|Early Syphilis	September 3, 2018	Phase 2
NCT03612557	Pfizer	Healthy	August 20, 2018	Phase 1
NCT02871505	Peking Union Medical College Hospital	Syphilis	August 2016	Phase 4
NCT01310361	Azad University of Medical Sciences	Streptococcal Sore Throat	January 2004	Phase 1
NCT02857959	Jun Li\|Peking Union Medical College Hospital	Syphilis	August 2016	Phase 4
NCT02611765	Baylor College of Medicine	Syphilis	September 2008	Phase 4
NCT03632642	The University of Queensland	Staphylococcus Aureus	July 1, 2019	Phase 4
NCT03346525	Children´s National Research Institute\|Thrasher Research Fund\|University of Cape Town\|Uganda Heart Institute\|Karp Family Foundation\|Gift of Life International\|Murdoch Childrens Research Institute	Rheumatic Heart Disease in Children\|Latent Rheumatic Heart Disease\|Rheumatic Heart Disease\|Heart Diseases	June 26, 2018	Phase 2
NCT00000648	National Institute of Allergy and Infectious Diseases (NIAID)\|Hoffmann-La Roche	HIV Infections\|Neurosyphilis		Not Applicable
NCT04876131	Murdoch Childrens Research Institute\|Royal Children´s Hospital	Complicated Urinary Tract Infection\|Infection\|Pediatric Infectious Disease	May 30, 2022	Phase 4

Appearance

Solid

Source

Penicillium

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 280.61 mM )

H ₂ O : ≥ 100 mg/mL ( 280.61 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8061 mL	14.0304 mL	28.0607 mL
5 mM	0.5612 mL	2.8061 mL	5.6121 mL
10 mM	0.2806 mL	1.4030 mL	2.8061 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (280.61 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, sodium salt (1:1)

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, monosodium salt

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-[2S-(2α,5α,6β)]-, monosodium salt

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, monosodium salt

Benzylpenicillinic acid sodium salt

Benzylpenicillin sodium

Benzylpenicillin sodium salt

Novocillin

Penicillin G sodium

Penilaryn

Sodium benzylpenicillin

Sodium benzylpenicillinate

Sodium penicillin G

Sodium penicillin II

Veticillin

Penicillin G sodium salt

Sodium benzylpenicillin G

Pen-A-Brasive

Sodium penicillin

Sodium 6-(phenylacetamido)penicillanate

Mycofarm

Crystapen

Monosodium benzylpenicillin

Monocillin

American penicillin

Nalpen G

Nobak

Ethacillin