[CAS NO. 6902-91-6] Germacrone

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PRODUCTS SPECIFICATIONS [6902-91-6]

Catalog

HY-N0440

Brand

MCE

CAS

6902-91-6

DESCRIPTION [6902-91-6]

Overview

MDL	-
Molecular Weight	218.33
Molecular Formula	C15H22O
SMILES	O=C1C/C(C)=C/CC/C(C)=C/C/C1=C(C)\C

For research use only. We do not sell to patients.

Summary

Germacrone is extracted from Rhizoma Curcuma . Germacrone inhibits influenza virus infection ^[1] .

IC50 & Target

Influenza virus ^[1]

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 458.02 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5802 mL	22.9011 mL	45.8022 mL
5 mM	0.9160 mL	4.5802 mL	9.1604 mL
10 mM	0.4580 mL	2.2901 mL	4.5802 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Liao Q, et al. Germacrone inhibits early stages of influenza virus infection. Antiviral Res. 2013 Dec;100(3):578-88.

Synonyms

3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (3E,7E)-

Germacrone

3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-

Germacra-3,7(11),9-trien-6-one, (E,E)-

(3E,7E)-3,7-Dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one

Germacron

(E,E)-Germacrone