[CAS NO. 697235-39-5] Episilvestrol
PRODUCTS SPECIFICATIONS [697235-39-5]
DESCRIPTION [697235-39-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 654.66 |
| Molecular Formula | C34H38O13 |
| SMILES | O=C([C@H]([C@H]1C2=CC=CC=C2)[C@@H](O)[C@]3(O)[C@@]1(C4=CC=C(OC)C=C4)OC5=CC(O[C@@H]6O[C@@H]([C@@H](O)CO)CO[C@H]6OC)=CC(OC)=C35)OC |
Summary
Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia perviridis , and is a specific eIF4A -targeting translation inhibitor, with antitumor activity.
IC50 & Target
|
eIF4 |
In Vitro
Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity [1] . Episilvestrol is cytotoxic activity against several human cancer cell lines, such as Lu1, LNCaP, MCF-7 and HUVEC cells, with ED 50 s of 3.8, 3.8, 5.5 and 15.3 nM, respectively [2] . The GI 50 s of Episilvestrol against the cell proliferation of NCI-H460 and MCF-7 cels are 17.96 nM and 17.96 nM after first test and 15.6 nM and 18.7 nM after 2 months via SRB assay. Episilvestrol also suppresses HK1 cells and EBV-positive C666.1 NPC cells [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 38.19 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5275 mL | 7.6376 mL | 15.2751 mL |
| 5 mM | 0.3055 mL | 1.5275 mL | 3.0550 mL |
| 10 mM | 0.1528 mL | 0.7638 mL | 1.5275 mL |
References
- [1] Chambers JM, et al. Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II. Org Lett. 2013 Mar 15;15(6):1406-9.
- [2] Hwang BY, et al. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J Org Chem. 2004 May 14;69(10):3350-8.
- [3] Daker M, et al. Inhibition of nasopharyngeal carcinoma cell proliferation and synergism of cisplatin with silvestrol and episilvestrol isolated from Aglaia stellatopilosa. Exp Ther Med. 2016 Jun;11(6):2117-2126. Epub 2016 Mar 29.
Synonyms