[CAS NO. 70-26-8] L-Ornithine

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PRODUCTS SPECIFICATIONS [70-26-8]

Catalog

HY-B1352

Brand

MCE

CAS

70-26-8

DESCRIPTION [70-26-8]

Overview

MDL	MFCD00242584
Molecular Weight	132.16
Molecular Formula	C5H12N2O2
SMILES	N[C@@H](CCCN)C(O)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]ChemistrySelect. 2023 Jan 12.

Summary

L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective ^[1] ^[2] .

IC50 & Target

Human Endogenous Metabolite

Microbial Metabolite

In Vitro

L-Ornithine (0-10 mM) activates the CaSR in a concentration-dependent manner and exerts effects on Ca ²⁺ signaling in HK-2 cells ^[2] .
L-Ornithine (10 mM) activates TRPC channels mediated Ca ²⁺ entry pathway in HK-2 cells ^[2] .
L-Ornithine (100 or 300 μM; 24 h) shows the protection against ROS generation in HK-2 cells via ROCE pathway ^[2] .
L-Ornithine (10 μM) can protect the ROS and oxidative damage in HK-2 cells exposed to H ₂ O ₂ ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05042024	Ukrainian Medical Stomatological Academy	Periodontitis	October 20, 2017	Phase 3
NCT00433368	Aga Khan University	Hepatic Encephalopathy	October 2003	Phase 3
NCT00470314	All India Institute of Medical Sciences, New Delhi	Acute Liver Failure	January 2005	Phase 2
NCT02158182	Hospital General de Mexico	Hepatic Encephalopathy	July 2014	Phase 4
NCT00305591	Imperial College London\|Royal College of Physicians\|Paddington Charitable Estates Educational Fund\|University of London	Cirrhosis\|Hepatic Encephalopathy	March 2006	Not Applicable
NCT01722578	Dayanand Medical College and Hospital	Cirrhosis of Liver\|Hepatic Encephalopathy	December 2013	Phase 4

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H ₂ O : 50 mg/mL ( 378.33 mM ; Need ultrasonic)

DMSO : 1.3 mg/mL ( 9.84 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5666 mL	37.8329 mL	75.6659 mL
5 mM	1.5133 mL	7.5666 mL	15.1332 mL
10 mM	0.7567 mL	3.7833 mL	7.5666 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

L-Ornithine

Ornithine, L-

Pentanoic acid, 2,5-diamino-, (S)-

Ornithine

L-(-)-Ornithine

(S)-2,5-Diaminopentanoic acid

(S)-Ornithine

(S)-α,δ-Diaminovaleric acid

(+)-S-Ornithine

L-Norvaline, 5-amino-

(2S)-2,5-Diaminopentanoic acid