[CAS NO. 700-49-2] 2-Fluoroadenine
PRODUCTS SPECIFICATIONS [700-49-2]
DESCRIPTION [700-49-2]
Overview
| MDL | MFCD01632749 |
|---|---|
| Molecular Weight | 153.12 |
| Molecular Formula | C5H4FN5 |
| SMILES | NC1=NC(F)=NC2=C1NC=N2 |
Summary
2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer [1] .
IC50 & Target
DNA/RNA synthesis [1]
In Vitro
2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis
[1]
.
2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity in nonproliferating MRC-5 cells
[1]
.
2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses in Balb-3T3 cells incubated in serum-free medium
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay
| Cell Line: | CEM cells [1] |
| Concentration: | 2 μM |
| Incubation Time: | 4 hours |
| Result: | Inhibited CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. |
Cell Cytotoxicity Assay
| Cell Line: | MRC-5 cells [1] |
| Concentration: | 0-1000 μM |
| Incubation Time: | 4 hours |
| Result: | Exhibited cytotoxicity in nonproliferating MRC-5 cells. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Synonyms