[CAS NO. 703-95-7] 5-Fluoroorotic acid

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PRODUCTS SPECIFICATIONS [703-95-7]

Catalog

HY-W016819

Brand

MCE

CAS

703-95-7

DESCRIPTION [703-95-7]

Overview

MDL	MFCD00042526
Molecular Weight	174.09
Molecular Formula	C5H3FN2O4
SMILES	O=C(C(NC1=O)=C(F)C(N1)=O)O

For research use only. We do not sell to patients.

Summary

5-Fluoroorotic is a selective agent in yeast molecular genetics. 5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 718.02 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.7442 mL	28.7208 mL	57.4416 mL
5 mM	1.1488 mL	5.7442 mL	11.4883 mL
10 mM	0.5744 mL	2.8721 mL	5.7442 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (11.95 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (11.95 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (11.95 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4-Pyrimidinecarboxylic acid, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-

Orotic acid, 5-fluoro-

5-Fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid

5-Fluoroorotic acid

Fluoroorotic acid

ENT 26398

NSC 31712

WR 152520

5-Fluoroorotate

NSC 143130

5-Fluoro-2,6-dihydroxypyrimidine-4-carboxylic acid