[CAS NO. 70375-43-8] SCH-202676

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PRODUCTS SPECIFICATIONS [70375-43-8]

Catalog

HY-133862

Brand

MCE

CAS

70375-43-8

DESCRIPTION [70375-43-8]

Overview

MDL	-
Molecular Weight	267.35
Molecular Formula	C15H13N3S
SMILES	C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1

For research use only. We do not sell to patients.

Summary

SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR) . SCH-202676 has antiviral activity and inhibits 3CL ^pro in a time-dependent manner with an IC ₅₀ value of 0.655 µM ^[1] ^[2] ^[3] ^[4] .

IC50 & Target

Adenosine A ₃ receptor

In Vitro

SCH-202676 (compound 6a) (0.01, 0.1, 1 and 10 µM; 0, 5, 10 and 20 min) shows antiviral activity and inhibits 3CL ^pro in a time-dependent manner, with IC ₅₀ values of 0.409, 0.302, 0.206 and 0.191 µM for 0, 5, 10 and 20 min, respectively ^[1] .
SCH-202676 (10 μM; 90 min) enhances the labelling of [ ³⁵ S]GTPγS in rat forebrain membranes ^[2] .
SCH-202676 inhibits the agonist [ ³ H]UK-14,304 (HY-B0659) and the antagonist [ ³ H] Yohimbine (HY-12715) binding to the α _2a adrenergic receptor ^[3] .
SCH-202676 (10 μM) selectively accelerates agonist dissociation at adenosine A3 receptors, slows antagonist dissociation at adenosine Ai receptors or accelerates antagonist dissociation at adenosine AzA receptors ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.