[CAS NO. 70831-56-0] L-Chicoric Acid
PRODUCTS SPECIFICATIONS [70831-56-0]
DESCRIPTION [70831-56-0]
Overview
| MDL | MFCD22683653 |
|---|---|
| Molecular Weight | 474.37 |
| Molecular Formula | C22H18O12 |
| SMILES | O=C(O[C@@H](C(O)=O)[C@H](C(O)=O)OC(/C=C/C1=CC=C(O)C(O)=C1)=O)/C=C/C2=CC=C(O)C(O)=C2.[Rotation(-)] |
1 Publications Citing Use of MCE
Summary
IC50 & Target
|
HIV-1 |
In Vitro
L-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 μM and higher. L-Chicoric Acid also inhibits integration as indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus. The EC
50
of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells
[1]
.
The ED
50
of L-Chicoric Acid against HIV
NL4-3
control virus is 400 nM, while HIV
NL4-3
passaged in the presence of 8 μM L-Chicoric Acid is completely resistant to the compound
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 210.81 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1081 mL | 10.5403 mL | 21.0806 mL |
| 5 mM | 0.4216 mL | 2.1081 mL | 4.2161 mL |
| 10 mM | 0.2108 mL | 1.0540 mL | 2.1081 mL |
References
- [1] Reinke RA, et al. L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology. 2004 Sep 1;326(2):203-19.
- [2] King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. J Virol. 1998 Oct;72(10):8420-4.
- [3] Robinson WE Jr. L-chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of a protease inhibitor (AG1350). Antiviral Res. 1998 Aug;39(2):101-11.
Synonyms