[CAS NO. 72-89-9] AcetylcoenzymeA

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [72-89-9]

Catalog

HY-114293

Brand

MCE

CAS

72-89-9

DESCRIPTION [72-89-9]

Overview

MDL	-
Molecular Weight	809.57
Molecular Formula	C23H38N7O17P3S
SMILES	O[C@H]1[C@@H](O[C@H](COP(OP(OCC(C)([C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)C)(O)=O)(O)=O)[C@H]1OP(O)(O)=O)N2C3=C(C(N)=NC=N3)N=C2

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis ^[1] ^[2] ^[3] ^[4] .

IC50 & Target

Human Endogenous Metabolite

In Vitro

Acetyl coenzyme A increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h) ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acetyl coenzyme A blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy ^[2] ^[3] . Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A concentrations in the brain and actually increase hepatic Acetyl coenzyme A and protein acetylation levels ^[4] .