[CAS NO. 724440-27-1] BAY-8002
PRODUCTS SPECIFICATIONS [724440-27-1]
DESCRIPTION [724440-27-1]
Overview
| MDL | MFCD05157149 |
|---|---|
| Molecular Weight | 415.85 |
| Molecular Formula | C20H14ClNO5S |
| SMILES | O=C(O)C1=CC=CC=C1NC(C2=CC(S(=O)(C3=CC=CC=C3)=O)=CC=C2Cl)=O |
3 Publications Citing Use of MCE
Summary
BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1) , with an IC 50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 . Anti-tumor activity [1] .
IC50 & Target
IC50: 85 nM (MCT1, in DLD-1 cells) [1]
In Vitro
BAY-8002 is an inhibitor of MCT1, with an IC 50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC 50 >50 µM in EVSA-T cells) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
BAY-8002 (80 and 160 mg/kg, p.o., twice daily, for more than 26 days) significantly inhibits tumor growth in Raji tumor-bearing mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Female NOD SCID mice bearing Raji cells (7-10 weeks old) [1] |
| Dosage: | 80 and 160 mg/kg |
| Administration: | P.O. twice daily for more than 26 days |
| Result: | Inhibited tumor growth with no obvious body weight loss, but showed no effect on tumor regression. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 300.59 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4047 mL | 12.0236 mL | 24.0471 mL |
| 5 mM | 0.4809 mL | 2.4047 mL | 4.8094 mL |
| 10 mM | 0.2405 mL | 1.2024 mL | 2.4047 mL |