[CAS NO. 72596-74-8] PD404182
PRODUCTS SPECIFICATIONS [72596-74-8]
DESCRIPTION [72596-74-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 217.29 |
| Molecular Formula | C11H11N3S |
| SMILES | N=C1SC2=CC=CC=C2C3=NCCCN13 |
1 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 9 μM (DDAH1) [1]
In Vitro
PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs
[1]
.
PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity
[1]
.
PD 404182 inhibits HIV-1 in seminal plasma, with an IC
50
of 1 μM
[2]
.
PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD
4+
T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Human dermal microvascular endothelial cells (ECs) |
| Concentration: | 10-300 μM |
| Incubation Time: | 24 hours |
| Result: | Did not induce cytotoxicity. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 230.11 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.6021 mL | 23.0107 mL | 46.0214 mL |
| 5 mM | 0.9204 mL | 4.6021 mL | 9.2043 mL |
| 10 mM | 0.4602 mL | 2.3011 mL | 4.6021 mL |
References
- [1] Ghebremariam YT, et, al. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther. 2014 Jan; 348(1): 69-76.
- [2] Chamoun-Emanuelli AM, et, al. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob Agents Chemother. 2014; 58(2): 687-97.