[CAS NO. 729607-74-3] BMS-707035
PRODUCTS SPECIFICATIONS [729607-74-3]
DESCRIPTION [729607-74-3]
Overview
| MDL | MFCD18074518 |
|---|---|
| Molecular Weight | 410.42 |
| Molecular Formula | C17H19FN4O5S |
| SMILES | FC1=CC=C(C=C1)CNC(C(N=C(N2C)N3S(CCCC3)(=O)=O)=C(C2=O)O)=O |
1 Publications Citing Use of MCE
Summary
BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC 50 value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) [1] .
In Vitro
BMS-707035 has antiviral activity with EC
50
values of 2 nM and 17 nM in the presence of 10% FBS and 15 mg/mL human serum albumin, respectively
[1]
.
BMS-707035 has high plasma protein binding and not overtly cytotoxicy to several cell lines, with CC
50
value of ≥45 μM
[1]
.
BMS-707035 has a relatively weak CYP inhibiton with IC
50
value of ≥40 μM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
BMS-707035 has a low clearance effect in the rat, dog and monkey with moderate to long elimination half-lives in all species
[1]
.
Pharmacokinetic Parameters of BMS-707035 in rat, dog and monkey (IV)
[1]
.
| Rat | Monkey | Dog | |
| IV dose (mg/kg) | 0.87 | 1 | 1 |
| CL (ml/min/kg) | 9.7 | 6.8 | 2.0 |
| T 1/2 (h) | 4.0 | 6.5 | 6.0 |
| V ss (L/kg) | 0.86 | 0.87 | 0.45 |
| PO dose (mg/kg) | 4.4 | 5 | 5.2 |
| C max (μM) | 4.51 | 6.12 | 72.8 |
| t max (h) | 0.25 | 0.25 | 0.25 |
| AUC (μM*h) | 19.1 | 19.2 | 162 |
| F (%) | 86 | 56 | 129 |
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00397566 | Bristol-Myers Squibb |
HIV Infections
|
February 2007 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 121.83 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4365 mL | 12.1826 mL | 24.3653 mL |
| 5 mM | 0.4873 mL | 2.4365 mL | 4.8731 mL |
| 10 mM | 0.2437 mL | 1.2183 mL | 2.4365 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution