[CAS NO. 729610-18-8] Calindol hydrochloride
PRODUCTS SPECIFICATIONS [729610-18-8]
DESCRIPTION [729610-18-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 336.86 |
| Molecular Formula | C21H21ClN2 |
| SMILES | C[C@@H](NCC1=CC2=CC=CC=C2N1)C3=C4C=CC=CC4=CC=C3.Cl |
Summary
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC 50 of 132 nM [1] .
In Vitro
In the presence of 2mM Ca
2+
, Calindol stimulates phosphatidylinositol (PI) accumulation with an EC
50
of 1.0 μM or 0.31 μM in cells expressing the rat or the human CaSR, respectively
[2]
.
In wire myography studies, Calindol (1-10 µM) inhibits Methoxamine- and KCl-induced pre-contracted tone, and inhibits whole-cell voltage-gated Ca
2+
channel (VGCC) currents in rabbit mesenteric arteries
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Lionel Kiefer, et al. Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists. Bioorg Med Chem. 2016 Feb 15;24(4):554-69.
- [2] Albane Kessler, et al. N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9.
- [3] Harry Z E Greenberg, et al. The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels. Eur J Pharmacol. 2016 Nov 15;791:659-668.