[CAS NO. 73029-73-9] CyPPA
PRODUCTS SPECIFICATIONS [73029-73-9]
DESCRIPTION [73029-73-9]
Overview
| MDL | MFCD01550586 |
|---|---|
| Molecular Weight | 285.39 |
| Molecular Formula | C16H23N5 |
| SMILES | CC1=CC(NC2CCCCC2)=NC(N3N=C(C)C=C3C)=N1 |
Summary
In Vitro
CyPPA induces a concentration-dependent increase in the apparent Ca 2+ -sensitivity of channel activation, changing the EC 50 (Ca 2+ ) from 429 nM to 59 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CyPPA, a positive modulator of small-conductance Ca 2+ -activated K + channels, inhibits phasic uterine contractions and delays preterm birth in mice [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 350.40 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5040 mL | 17.5199 mL | 35.0398 mL |
| 5 mM | 0.7008 mL | 3.5040 mL | 7.0080 mL |
| 10 mM | 0.3504 mL | 1.7520 mL | 3.5040 mL |
References
- [1] Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Br J Pharmacol. 2007 Jul;151(5):655-65.
- [2] Dana V Skarra, et al. CyPPA, a positive modulator of small-conductance Ca(2+)-activated K(+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1027-35.
Synonyms