[CAS NO. 73465-43-7] 1-Deoxymannojirimycin hydrochloride
PRODUCTS SPECIFICATIONS [73465-43-7]
DESCRIPTION [73465-43-7]
Overview
| MDL | MFCD00083611 |
|---|---|
| Molecular Weight | 199.63 |
| Molecular Formula | C6H14ClNO4 |
| SMILES | O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)NC1.Cl |
Summary
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 500.93 mM ; Need ultrasonic)
H 2 O : 100 mg/mL ( 500.93 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.0093 mL | 25.0463 mL | 50.0927 mL |
| 5 mM | 1.0019 mL | 5.0093 mL | 10.0185 mL |
| 10 mM | 0.5009 mL | 2.5046 mL | 5.0093 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (500.93 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (12.52 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (12.52 mM); Clear solution
References
- [1] F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98.
- [2] Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4.