[CAS NO. 7424-00-2] Fenclonine

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PRODUCTS SPECIFICATIONS [7424-00-2]

Catalog

HY-B1368

Brand

MCE

CAS

7424-00-2

DESCRIPTION [7424-00-2]

Overview

MDL	-
Molecular Weight	199.63
Molecular Formula	C9H10ClNO2
SMILES	NC(CC1=CC=C(Cl)C=C1)C(O)=O

For research use only. We do not sell to patients.

10 Publications Citing Use of MCE

Summary

Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research ^[1] ^[2] ^[3] .

In Vivo

Fenclonine (intraperitoneal injection; 100 mg/kg; once daily; 3 d) treatment can inhibit Morphine-induced anti-nociceptive activity ^[2] .
Fenclonine (intraperitoneal injection; 300 mg/kg; once daily; 3 d) pretreatment completely abolishes the effects of a 50 mg/kg dose of Paracetamol ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar albino rats of either sex and weighing between 80 and 100 g ^[2]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; 100 mg/kg; once daily; 3 days
Result:	Inhibited the antinociceptive activity of Morphine by 41.5%.

Animal Model:	Male Swiss mice (22–25 g) ^[3]
Dosage:	300 mg/kg
Administration:	Intraperitoneal injection; 300 mg/kg; once daily; 3 days
Result:	Inhibited the effects of Paracetamol in depression-like and compulsion-like behavior.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 500.93 mM ; ultrasonic and adjust pH to 2 with HCl)

H ₂ O : 4.55 mg/mL ( 22.79 mM ; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0093 mL	25.0463 mL	50.0927 mL
5 mM	1.0019 mL	5.0093 mL	10.0185 mL
10 mM	0.5009 mL	2.5046 mL	5.0093 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 0.5% CMC-Na /saline water

Solubility: 20 mg/mL (100.19 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (12.52 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.52 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.52 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Phenylalanine, 4-chloro-

Alanine, 3-(p-chlorophenyl)-, DL-

DL-Phenylalanine, 4-chloro-

4-Chlorophenylalanine

CP 10188

Fenclonine

DL-p-Chlorophenylalanine

Fenchlonine

DL-4-Chlorophenylalanine

p-Chloro-DL-phenylalanine

(±)-p-Chlorophenylalanine

4-Chloro-DL-phenylalanine

DL-3-(p-Chlorophenyl)alanine

Fenclonin

3-(p-Chlorophenyl)alanine

p-Chlorophenylalanine

NSC 77370

2-Amino-3-(4-chlorophenyl)propanoic acid

2-Amino-3-(4-chloro-phenyl)-propionic acid