[CAS NO. 7432-28-2] Schisandrin

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PRODUCTS SPECIFICATIONS [7432-28-2]

Catalog

HY-N0691

Brand

MCE

CAS

7432-28-2

DESCRIPTION [7432-28-2]

Overview

MDL	MFCD00905761
Molecular Weight	432.51
Molecular Formula	C24H32O7
SMILES	O[C@]1(C)[C@@H](C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C(OC)C(OC)=C(OC)C=C3C1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Eur J Pharmacol. 2019 Jul 15;855:10-19.

Summary

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats ^[1] ^[2] ^[3] .

In Vitro

Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells ^[1] .
Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages ^[1] .
Schisandrin inhibits the SK-HEP-1, SNU-638, and T47D cells proliferation, with IC ₅₀ s of 42.0, 53.1, and 40.0 μM, respectively ^[3] .
Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	RAW 264.7 macrophages
Concentration:	12.5, 25, 50, 100 μM
Incubation Time:	Pretreated for 2 h and then incubated with LPS (1 μg/mL) for 18 h
Result:	Markedly decreased iNOS protein expression a dose-dependent manner. Significantly inhibited COX-2 protein expression.

In Vivo

Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice ^[1] .
Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice (4-weeks) were treated with λ-carrageenan by intraperitoneal injection into the right hind paw ^[1]
Dosage:	100, 200 mg/kg
Administration:	A single i.p.
Result:	Inhibited paw edema by 33.43 % (100 mg/kg) and 57.38 % (200 mg/kg) at 3 h.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 1 mg/mL ( 2.31 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3121 mL	11.5604 mL	23.1209 mL
5 mM	---	---	---
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.28 mg/mL (0.65 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7S,12aR)-

Schizandrin

(6S,7S,12aR)-5,6,7,8-Tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-6-ol

Schisandrin

Schisandrine

Schizandrine

Wuweizichun A

Wuweizi alcohol A

(+)-Schizandrin

Schizandrol

Schisandrol A