[CAS NO. 757192-67-9] EN106

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PRODUCTS SPECIFICATIONS [757192-67-9]

Catalog

HY-W229874

Brand

MCE

CAS

757192-67-9

DESCRIPTION [757192-67-9]

Overview

MDL	MFCD06340076
Molecular Weight	280.71
Molecular Formula	C13H13ClN2O3
SMILES	O=C(N(CCC#N)C1=CC=C(OCCO2)C2=C1)CCl

For research use only. We do not sell to patients.

Summary

EN106 is a potent inhibitor of FEMIB . EN106 is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1 ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 890.60 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5624 mL	17.8120 mL	35.6240 mL
5 mM	0.7125 mL	3.5624 mL	7.1248 mL
10 mM	0.3562 mL	1.7812 mL	3.5624 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022;144(2):701-708.

Synonyms

Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-

2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide