[CAS NO. 764-22-7] D-Erythro-dihydrosphingosine
PRODUCTS SPECIFICATIONS [764-22-7]
DESCRIPTION [764-22-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 301.51 |
| Molecular Formula | C18H39NO2 |
| SMILES | CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO |
Summary
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A 2 α ( cPLA 2 α ) activity.
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na 3 VO 4 -, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [ 3 H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA 2 α activity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
Ethanol : 50 mg/mL ( 165.83 mM ; Need ultrasonic)
DMSO : 10 mg/mL ( 33.17 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3166 mL | 16.5832 mL | 33.1664 mL |
| 5 mM | 0.6633 mL | 3.3166 mL | 6.6333 mL |
| 10 mM | 0.3317 mL | 1.6583 mL | 3.3166 mL |
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1.
Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.29 mM); Clear solution
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2.
Add each solvent one by one: 10% EtOH >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.29 mM); Clear solution
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3.
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4.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution
-
5.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution
Synonyms