[CAS NO. 76530-44-4] Azamulin
PRODUCTS SPECIFICATIONS [76530-44-4]
DESCRIPTION [76530-44-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 478.65 |
| Molecular Formula | C24H38N4O4S |
| SMILES | C[C@@H]1[C@]23[C@](C(CC3)=O)([H])[C@]([C@@H](C[C@](C)([C@H]1O)CC)OC(CSC4=NN=C(N)N4)=O)([C@@H](CC2)C)C |
Summary
Azamulin is an irreversible, highly selective inhibitior of human CYP3Aa . Azamulin has CYP3A inhibition activity with IC 50 values range from 0.03-0.24 μM. Azamulin can be used for the research of metabolism and antiinfection [1] .
IC50 & Target
|
CYP3A 0.03-0.24 μM (IC 50 ) |
In Vitro
Azamulin has CYP3A inhibition activity with IC
50
values range from 0.03-0.24 μM
[1]
.
Azamulin has CYP3A inhibition appeared sigmoidal and well behaved with the substrates 7-benzyloxy-4-trifluoromethylcoumarin, testosterone, and midazolam
[1]
.
Azamulin (4.8 μM；10 min) inhibits approximately 95% of testosterone 6beta-hydroxylase activity in the presence of NADPH
[1]
.
Azamulin exhibits good chemical stability when stored in acetonitrile for up to 12 days
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.