[CAS NO. 7758-73-8] LC3-mHTT-IN-AN2
PRODUCTS SPECIFICATIONS [7758-73-8]
DESCRIPTION [7758-73-8]
Overview
| MDL | MFCD01078551 |
|---|---|
| Molecular Weight | 254.24 |
| Molecular Formula | C15H10O4 |
| SMILES | OC1=C2C(OC(C=C2C3=CC=CC=C3)=O)=CC(O)=C1 |
Summary
LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons [1] .
IC50 & Target
mHTT-LC3 Linker Compound
In Vitro
LC3-mHTT-IN-AN2 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 491.66 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9333 mL | 19.6665 mL | 39.3329 mL |
| 5 mM | 0.7867 mL | 3.9333 mL | 7.8666 mL |
| 10 mM | 0.3933 mL | 1.9666 mL | 3.9333 mL |