[CAS NO. 78842-13-4] 2′-Deoxy-2′-fluoroguanosine

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PRODUCTS SPECIFICATIONS [78842-13-4]

Catalog

HY-W011518

Brand

MCE

CAS

78842-13-4

DESCRIPTION [78842-13-4]

Overview

MDL	MFCD00923832
Molecular Weight	285.23
Molecular Formula	C10H12FN5O4
SMILES	OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O1

For research use only. We do not sell to patients.

Summary

2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC ₉₀ of <0.35 μM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation ^[1] ^[2] .

IC50 & Target

EC90: <0.35 μM (influenza virus A and B) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 175.30 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5059 mL	17.5297 mL	35.0594 mL
5 mM	0.7012 mL	3.5059 mL	7.0119 mL
10 mM	0.3506 mL	1.7530 mL	3.5059 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.76 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.76 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.76 mM); Clear solution

* All of the co-solvents are available by MCE.