[CAS NO. 790245-61-3] NCT02

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PRODUCTS SPECIFICATIONS [790245-61-3]

Catalog

HY-W181530

Brand

MCE

CAS

790245-61-3

DESCRIPTION [790245-61-3]

Overview

MDL	-
Molecular Weight	312.39
Molecular Formula	C17H16N2O2S
SMILES	O=C(NC1=NC=C(C)S1)CC2=COC3=CC4=C(CCC4)C=C32

For research use only. We do not sell to patients.

Summary

NCT02 is a cyclin K degrader. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12 . NCT02 has the potential for the research of metastatic colorectal cancer (CRC) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 160.06 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2011 mL	16.0056 mL	32.0113 mL
5 mM	0.6402 mL	3.2011 mL	6.4023 mL
10 mM	0.3201 mL	1.6006 mL	3.2011 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Dieter SM, et al. Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 2021;36(3):109394.