[CAS NO. 794572-10-4] ML-184
PRODUCTS SPECIFICATIONS [794572-10-4]
DESCRIPTION [794572-10-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 470.63 |
| Molecular Formula | C25H34N4O3S |
| SMILES | CC1=CC=CC(N2CCN(CC2)C(C3=CC(S(N(C)C)(=O)=O)=CC=C3N4CCCC4)=O)=C1C |
Summary
ML-184 (CID2440433) is a selective GPR55 agonist with an EC 50 of 250 nM and exhibits >100-fold selectivity for GPR55 over GPR35 , CB1 and CB2 . ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55 [1] . ML-184(CID2440433) increases proliferation of neural stem cells and promotes neuronal differentiation in vitro [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 12.5 mg/mL ( 26.56 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1248 mL | 10.6241 mL | 21.2481 mL |
| 5 mM | 0.4250 mL | 2.1248 mL | 4.2496 mL |
| 10 mM | 0.2125 mL | 1.0624 mL | 2.1248 mL |
References
- [1] Kotsikorou E, et al. Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47.
- [2] Hill JD, et al. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Aug;175(16):3407-3421.