[CAS NO. 81422-93-7] Sanggenon D

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PRODUCTS SPECIFICATIONS [81422-93-7]

Catalog

HY-N0618

Brand

MCE

CAS

81422-93-7

DESCRIPTION [81422-93-7]

Overview

MDL	-
Molecular Weight	708.71
Molecular Formula	C40H36O12
SMILES	C/C(C)=C/CC(C1=O)(OC2=CC(O)=CC=C32)C3(OC4=C1C(O)=C(C(C=C(C)CC5C(C=CC(O)=C6)=C6O)C5C(C(C=CC(O)=C7)=C7O)=O)C(O)=C4)O

For research use only. We do not sell to patients.

Summary

Sanggenon D is a Diels-Alder-type adduct from Chinese crude drug root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC ₅₀ of 0.77 μM ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 141.10 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4110 mL	7.0551 mL	14.1101 mL
5 mM	0.2822 mL	1.4110 mL	2.8220 mL
10 mM	0.1411 mL	0.7055 mL	1.4110 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Hou XD , et al. Natural constituents from Cortex Mori Radicis as new pancreatic lipase inhibitors. Bioorg Chem. 2018 Oct;80:577-584.

Synonyms

11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,5a,8-tetrahydroxy-10a-(3-methyl-2-buten-1-yl)-

11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,5a,8-tetrahydroxy-10a-(3-methyl-2-butenyl)-

2-[6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,5a,8-tetrahydroxy-10a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one

Sanggenone D

Sanggenon D

2-(2-(2,4-Dihydroxybenzoyl)-2′,4′-dihydroxy-5-methyl-1,2,3,6-tetrahydro-[1,1′-biphenyl]-3-yl)-1,3,5a,8-tetrahydroxy-10a-(3-methylbut-2-en-1-yl)-5aH-benzofuro[3,2-b]chromen-11(10aH)-one