[CAS NO. 823218-99-1] SN2

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PRODUCTS SPECIFICATIONS [823218-99-1]

Catalog

HY-16696

Brand

MCE

CAS

823218-99-1

DESCRIPTION [823218-99-1]

Overview

MDL	MFCD09266779
Molecular Weight	255.35
Molecular Formula	C17H21NO
SMILES	CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

SN 2 is a potent activator of TRPML3 ion channel with an EC ₅₀ of 1.8 μM ^[1] . SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) ^[2] .

IC50 & Target

EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1) ^[1]

In Vitro

The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05484388	Essity Hygiene and Health AB\|Smerud Medical Research Germany Ltd	Urinary Incontinence	October 3, 2022	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 391.62 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9162 mL	19.5810 mL	39.1619 mL
5 mM	0.7832 mL	3.9162 mL	7.8324 mL
10 mM	0.3916 mL	1.9581 mL	3.9162 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

* All of the co-solvents are available by MCE.