[CAS NO. 835616-61-0] Thalidomide 5-fluoride

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PRODUCTS SPECIFICATIONS [835616-61-0]

Catalog

HY-W087383

Brand

MCE

CAS

835616-61-0

DESCRIPTION [835616-61-0]

Overview

MDL	MFCD30188075
Molecular Weight	276.22
Molecular Formula	C13H9FN2O4
SMILES	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(F)=C3)=O

For research use only. We do not sell to patients.

Summary

Thalidomide 5-fluoride is Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

IC50 & Target

Cereblon

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL ( 301.68 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6203 mL	18.1015 mL	36.2030 mL
5 mM	0.7241 mL	3.6203 mL	7.2406 mL
10 mM	0.3620 mL	1.8102 mL	3.6203 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-

2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione

2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione

2-(2,6-Dioxo-3-piperidyl)-5-fluoroisoindoline-1,3-dione

2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindole-1,3-dione