[CAS NO. 835621-11-9] Regorafénib N-oxyde (M2)

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PRODUCTS SPECIFICATIONS [835621-11-9]

Catalog

HY-I0678

Brand

MCE

CAS

835621-11-9

DESCRIPTION [835621-11-9]

Overview

MDL	MFCD28343981
Molecular Weight	498.81
Molecular Formula	C21H15ClF4N4O4
SMILES	FC1=CC(OC2=CC=[N+]([O-])C(C(NC)=O)=C2)=CC=C1NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O

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Summary

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ , Kit, RET and Raf-1 with IC ₅₀ s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 100.24 mM ; Need ultrasonic)

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Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0048 mL	10.0239 mL	20.0477 mL
5 mM	0.4010 mL	2.0048 mL	4.0095 mL
10 mM	0.2005 mL	1.0024 mL	2.0048 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.