[CAS NO. 84-79-7] Lapachol

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PRODUCTS SPECIFICATIONS [84-79-7]

Catalog

HY-N6961

Brand

MCE

CAS

84-79-7

DESCRIPTION [84-79-7]

Overview

MDL	MFCD00001679
Molecular Weight	242.27
Molecular Formula	C15H14O3
SMILES	O=C(C(CC=C(C)C)=C1O)C2=CC=CC=C2C1=O

For research use only. We do not sell to patients.

Summary

Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae) ^[1] . Lapachol shows anti-abscess, anti-ulcer, antileishmanial, anticarcinomic, antiedemic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, antibacterial, antifungal and pesticidal activities ^[2] .

IC50 & Target

Plasmodium

Leishmania

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 412.76 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1276 mL	20.6381 mL	41.2763 mL
5 mM	0.8255 mL	4.1276 mL	8.2553 mL
10 mM	0.4128 mL	2.0638 mL	4.1276 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.32 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1,4-Naphthalenedione, 2-hydroxy-3-(3-methyl-2-buten-1-yl)-

Lapachol

1,4-Naphthoquinone, 2-hydroxy-3-(3-methyl-2-butenyl)-

1,4-Naphthalenedione, 2-hydroxy-3-(3-methyl-2-butenyl)-

2-Hydroxy-3-(3-methyl-2-buten-1-yl)-1,4-naphthalenedione

C.I. 75490

Bethabarra Wood

C.I. Natural Yellow 16

2-Hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone

Ipe-tobacco Wood

Lapachol Wood

Surinam Greenheart Wood

Taiguic acid

Taigu Wood

Tecomin

NSC 11905

Greenhartin

2-Hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione

NSC 629756

2-Hydroxy-3-(3-methylbut-2-en-1-yl)-1,4-dihydronaphthalene-1,4-dione